Lock Richie Gray and back row Luke Crosbie will miss the rest of Scotland’s Six Nations campaign after sustaining injuries in the dramatic opening win over Wales.
Gray has damaged a bicep, while Crosbie has a shoulder problem.
Full-back Blair Kinghorn is expected to miss Saturday’s home match with France after a knee issue kept him out of the 27-26 victory in Cardiff.
Winger Darcy Graham is also missing from Gregor Townsend’s squad.
Graham, who picked up a quadricep injury last month, is to resume training with Edinburgh this week, along with experienced prop WP Nel.
Co-captain Rory Darge did not feature against Wales, with head coach Townsend suggesting last week that he could be fit in time to face the French at Murrayfield.